0<< DBOBJSDEFFORMFLDNAMESINDEX0INDEX57WANTSKSWSFIELDS0!1!1X !1!1 D HQDNNQ"Z^$Z"&42}.e&o(*.`6e#,{,#*;Y]22(jV [F8pL& %$b |F"g{*|6Vy FF9y0*(rCtNnF}:<O~o.HLf\0Btx'xW { y |]a]a9%}# zZt#J ; :%%۷$ E =Vt ٻUt W,v$p%$ $|$n%&/&k&s&&&( zWt( ִXt*, k\t,x%,q%,Όr%,Όs%, ,,.4Lt.dMt.Nt.PE~%.PE%../.s#.s.2[2* 2* 4 {%4 |%4ut%4uu%44|4}4#6G(Ot6Qt6fm%8Yt:kx%:y%:O:WH<3s}%<^z%^` hb s0RU!1!1uu>C:\TudorData\SunsetMolecular\Wombat2004\wb2004_histH1GPCRs.dbRootIDSMDL.ID SMDL.IDx SMDL.SIDmol.ref mol.name mol.gnamemol.str *Structuremol.smimol.kwkw est.logkow est.logwsol exp.logkow exp.logwsol act.listidtypevalueminmaxinhib target.type target.name bio.speciesbio.tissuetypebio.tissuesource bio.cellbio.intracellstr bio.stimulus bio.effect swissp.idswissp.species enz.family enz.name enz.typeenz.ecenz.substrate enz.reactant enz.cofactorenz.radiosubstrate enz.actdet rec.family rec.name rec.type pro.family pro.name pro.typebind.endogenligandbind.radioligandbind.nonspecificother*fmla_mol.str*mol.weight_mol.str*ctab_mol.str*keys_mol.str*exact_mol.str antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamine + D' [ffr@333333@rh|SMDL-00000472-Bioorg. Med. Chem. Lett. 12(2)-2002 243-2482a!-x8G}&D˖ ,??LFp " v  @0 LxQx $< = > ? @ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcd e f!g!h"i"j#k#nsotp u        l qmr      ( 0 8!"@#$$$%&'()*+,-./0123456 7 8 9 : ; dm     $CN(C)CC1CC2N(O1)c3ccccc3Cc4ccccc24oes TPF"X !JĂEC&S UuH`\ċ`$`aY^T^YY5^3NF|eFPc6ޭʃdd$2X& y=DtQ: b B %p K%jF'lI1|[8 b F""%$p$&L&&*(o(X*,,}.S0622~4\6F8::6<~<>^>>F@@0BxBD\DDDFF2HzHJ_JJHLL;NN'PoPBRyPLT'VoVXVXXAZZ\f\^O^^;``!bhbdHdd8ffhahjHjj;ll'nrnp_plKrrrstuvwxyz{|}0EtU!1!1dm +  IC508.72008.72008.7200 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150  !"#$%&'()*+  IC508.42008.42008.4200 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine ,./0123456789:;<=  -?D%(@t@Q@|?5SMDL-00000470 -Bioorg. Med. Chem. Lett. 12(2)-2002 243-248 1 R-95292 (CN(C)CC1CC2N(O1)c3cc(Cl)ccc3Oc4ccccc24wuu TPN ,HJԠC)p/$ZBʩJ<!Q"d(ŚK sMo:X QLbVc R:VoBFȟR1-+ͱqÅü]۠;H1V-{` ! -x8G}'D . ,     ? abs  IC506.99006.99006.9900 receptorH1human cloned CHO cell antagonistP35367humanGPCRhistaminergic receptor[3H]pyrilamine>@ABCDEFGHIJKLMNO gIC507.98007.98007.9800 receptor5-HT2Ahuman:cloned L929 cell antagonistP28223humanxGPCRserotonergic receptor@[125I]R-91150[^_`abcdefghijklm IC508.13008.13008.1300 receptor5-HT2Chuman cloned CHO cell antagonistP28335humanGPCRserotonergic receptor3[3H]mesulergineenpqrstuvwxyz{|}~  \o D%"p@ @\(\]SMDL-00000471-Bioorg. Med. Chem. Lett. 12(2)-2002 243-2483 mianserin CN1CCN2C(C1)c3ccccc3Cc4ccccc24eEo T(Q ZUJԩAP2İH'*5ʇR,%Ҝ6u6̧R"$'ht/}/t:&L!N 8;8!/m?,X8*MD /m,PRSTUVZXWY7IC508.47008.47008.4700 receptorH1humancloned CHO cell vnh"  | 6 z p f \ P F < 2 * $ t ~ , p j : ( 4bt Z R H > 0 $     \B:0& pvld^:@J$P*4~Ztb IC507.64007.64007.6400 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150        IC507.91007.91007.9100 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine  !"#$%&  (abs IC508.17008.17008.1700 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamine')*+,-./012345678  dmCF + GI DHKIC507.04007.04007.0400 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150 MPQRSTUVWXYZ[\]^_  IC507.43007.43007.4300 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor[3H]mesulergine`bcdefghijklmnopq  NasD)ĠiQFs@E)\(@~jtOSMDL-00000473-Bioorg. Med. Chem. Lett. 12(2)-2002 243-2482b%CN(C)CCC1CC2N(O1)c3ccccc3Cc4ccccc24suu TPe+:d+QJ ><`!>(>خhHyyēgǙ'rFs&ҕ99)yؾ @!-X8oG}&Ò nt,9;<=>B@?A??oabs1JL N@IC507.08007.08007.0800 receptorH1humancloned CHO cell antagonistP35367humanGPCRhistaminergic receptor[3H]pyrilaminertuvwxyz{|}~ dmrF+@8o IC508.41008.41008.4100 receptor5-HT2Ahumancloned L929 cell antagonistP28223humanGPCRserotonergic receptor[125I]R-91150 IC507.73007.73007.7300 receptor5-HT2Chumancloned CHO cell antagonistP28335humanGPCR    D+Ԡ0 GD't@Q@&\SMDL-00000474-Bioorg. Med. Chem. Lett. 12(2)-2002 243-2482c&CN(C)CCCC1CC2N(O1)c3ccccc3Cc4ccccc24ww TPeAƊ ZN!Smx B\kskN1VOSR|z/h}h=N9ь׳CS|!h̶̏L*) 2 RoS.k!-X8oG}&Ò ,??abs    $ x l b X N F @ X`j " ,  2  V ~ P  $RV < 4 *   h P6.$ d~tj`XR .4>D(`<hVhhNF<2$zzpf^X|rdVLB8,"P pserotonergic receptor [3H]mesulergine  IC506.17006.17006.1700 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamine              dm #  + $ &  ! % ( IC507.37007.37007.3700 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150 * - . / 0 1 2 3 4 5 6 7 8 9 : ; <   IC507.84007.84007.8400 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine = ? @ A B C D E F G H I J K L M N   + > P D+Ԡ0 GD't@" Q@&\, SMDL-00000475 -Bioorg. Med. Chem. Lett. 12(2)-2002 243-248 2e&CCN(CC)CC1CC2N(O1)c3ccccc3Cc4ccccc24ww TPF"X !JĂEC2bPTL%T}x B \crepU /Ny}g5z /Sْ{rgwgɌ{8BϬ{j(r2e-e !-x8G}&ؠD˖  ,         ?? abs ' )  IC507.87007.87007.8700 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamineO Q R S T U V W X Y Z [ \ ] ^ _ `   dmk n C50+eo q C l p s IC50 <6.0000 receptor5-HT2Ahumancloned L929 cell antagonistP28223humanGPCRserotonergic receptor[125I]R-91150u x y z { | } ~   IC506.49006.49006.4900 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor[3H]mesulergine@   v D/3"u@m yGz@ETw SMDL-00000476-Bioorg. Med. Chem. Lett. 12(2)-2002 243-248a2f,CC(C)N(CC1CC2N(O1)c3ccccc3Cc4ccccc24)C(C)C{ TPFE`*'N*HQ.\*DWN -O0FO;޸n<'姡 șHMM!-x8G}&ؠD˖ 3,a c d e f j h g i ??0absr t ed.IC506.82006.82006.8200 receptorH1humanccloned CHO cell antagonistP35367humanGPCRhistaminergic receptor[3H]pyrilamine  .D)(*w@ RQ@K SMDL-00000477-Bioorg. Med. Chem. Lett. 12(2)-2002 243-2482g!8/8g&L˖ ,    ?? antagonistP28223humanGPCRvlbT n N z n d Z T H > 4 * "  f z p b V L B 8 , "    P P6.$ X b   " f vlfZPF<4.xvlbXLB8.& ppVND:, x(<zth^TJB<. ~dm   +    IC50 <6.0000 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150                  IC506.16006.16006.1600 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine  ! " # $ % & ' ( ) * + , - . / 0    2 0CN(CC1CC2N(O1)c3ccccc3Cc4ccccc24)C(=O)C(F)(F)F} T$BBP)Q-81u.a<ε;c56Z4X¬W>..7Vn6n۶wjx=;T=s 6%6 D8 abs   IC50 <6.0000 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamine1 3 4 5 6 7 8 9 : ; < = > ? @   dmK N  + O Q  L P S IC507.88007.88007.8800 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150 U X Y Z [ \ ] ^ _ ` a b c d e f g   IC508.15008.15008.1500 receptor5-HT2Chuman cloned CHO cell antagonistP28335humanGPCRserotonergic receptor[3H]mesulergineh j k l m n o p q r s t u v w x y   V i { D%ۊeq@M \(\@\(\W SMDL-00000478-Bioorg. Med. Chem. Lett. 12(2)-2002 243-2482h!CNCC1CC2N(O1)c3ccccc3Cc4ccccc24kUq TPejT B* :!I)dj:PA0b*22b^v/_F/rug%,r%V(}}汜4D%Dep:tp!j,x9G}&D˖ @j,A C D E F J H G I ??abscR T oniIC507.97007.97007.9700 receptorH1human5cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilaminez | } ~   dm MDL+. 43- IC507.80007.80007.8000 receptor5-HT2Ahumancloned L929 cell antagonistP28223humanCGPCRserotonergic receptor[125I]R-91150  A 9 D# pp@ (\ @\(\ SMDL-000004799-Bioorg. Med. Chem. Lett. 12(2)-2002 243-248P2j NCC1CC2N(O1)c3ccccc3Cc4ccccc24gEo TPej BT:İH25ʇ( 1Ut x1u//vV9}ˆc}*>>"m":828!3,x9G}&D˖ e., ??abs 9, ??humancloned L929 cell h^T Nx v l b X L B 8 . & p     >  6   H <"Pvj`VLD>|  *0 @  TBH v T:2(f& :~tj`TH@:x&, vIC508.25008.25008.2500 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine      IC506.70006.70006.7000 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamine !"#  + .1 abs 24 /36IC507.24007.24007.2400 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150 8;<=>?@ABCDEFGHIJ  IC507.86007.86007.8600 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine KMNOPQRSTUVWXYZ[\  9L^D)ĠiQFs@0@ r:SMDL-00000480 -Bioorg. Med. Chem. Lett. 12(2)-2002 243-248 2k'CN(C)CC1(C)CC2N(O1)c3ccccc3Cc4ccccc24 uuu$TQD*h$ J+Q ><`!"pU}<%8=FFF腼LK˝%E4&.pE4WD0 RF/TnȡlHMM!~-x]8g}&ȝd˖ ~,$&'()-+*,??easu@57anIC508.78008.78008.7800 receptorH1humanecloned CHO cell antagonistP35367humanGPCRhistaminergic receptor[3H]pyrilamine]_`abcdefghijklmn +oy|orabs}S z~IC50 <6.0000 receptor5-HT2Ahumancloned L929 cell antagonistP28223humanGPCRserotonergic receptor [125I]R-91150 IC506.03006.03006.0300 receptor5-HT2Chumancloned CHO cell antagonistP28335humanGPCRserotonergic receptor@[3H]mesulergine@ 0 D)ĠiQFs@{@ rSMDL-00000481-Bioorg. Med. Chem. Lett. 12(2)-2002 243-2482l'CN(C)CC1(C)CC2N(O1)c3ccccc3Cc4ccccc24uuu$TQD*h$ J+Q ><`!"pU}<%8=FFF腼LK˝%E4&.pE4WD0 RF/TnȡlHMM!~-x]8g}&ȝd˖ ~,oqrstxvuw??asuIC507.21007.21007.2100 receptorH1humancloned CHO cell antagonistP35367humanGPCRhistaminergic receptor[3H]pyrilamine  x n d ^ R H > 4 , & p z n d Z P D : 0 &   h h N F < 2 $   p z     6  ~  |pf\RJDxnbXND<6ldZPB4*  .,4>*T$&|rh^VPzpbVLB8," xdm   +   IC507.60007.60007.6000 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150  !"#$%  IC507.79007.79007.7900 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine &()*+,-./01234567  '9D+Ġut@ Gz@Q8SMDL-00000482 -Bioorg. Med. Chem. Lett. 12(2)-2002 243-248 2m(C(C1CC2N(O1)c3ccccc3Cc4ccccc24)N5CCCC5yy TPF"X  !JjUCbQTL%T}Hk`W\\Ë_$_َԷ^33D|EPcc,{߬JibdK !s,x8G}&ؠD  abs  IC508.52008.52008.5200 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamine8:;<=>?@ABCDEFGHI  dmTW + XZ UY\IC506.85006.85006.8500 receptor5-HT2Ahuman)cloned L929 cellC antagonistP28223humanbGPCRserotonergic receptor_[125I]R-91150^abcdefghijklmnop eIC50 <6.0000 receptor5-HT2Chumancloned CHO cell antagonistP28335humanGPCRserotonergic receptor[3H]mesulergineqstuvwxyz{|}~  _rD+Ġ(Pu@VGzG@1Zd`SMDL-00000483-Bioorg. Med. Chem. Lett. 12(2)-2002 243-2482n)C(C1CC2N(O1)c3ccccc3Cc4ccccc24)N5CCOCC5-{ TPF"X Z*X:dJE:@!5/WW }V2--wv7|*:_9̸=/<؟$f: 2 R6Z6!$ s,x8G}&ؠD $,JLMNOSQPR??abs[]IC507.58007.58007.5800 receptorH1humancloned CHO cell antagonistP35367humanGPCRhistaminergic receptor[3H]pyrilamine dm@[3+ IC506.55006.55006.5500 receptor5-HT2A  D- u@Q@VSMDL-00000484-Bioorg. Med. Chem. Lett. 12(2)-2002 243-2482q*CN1CCN(CC2CC3N(O2)c4ccccc4Cc5ccccc35)CC1} TPF"XU X&VzPDXHR1Pьxu0ZA0k v *)/*/Y}*[o[n/mtV-/V?a1'"r"1zvhyv@%e@t@Jlʥl!R,x8G}&D <R,??abs@  * nv \ 2 V &  :h ~ t j b \  znbZTxn`RH>4( LD L V 6  b 0  > ~vp$8 L|rf\RH@:X`j&,P,P> serotonergic receptor [125I]R-91150 IC50 <6.0000 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine        IC50 <6.0000 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamine !"#  dm.1 + 24 /36IC50 <6.0000 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150 8;<=>?@ABCDEFGH  IC50 <6.0000 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine IKLMNOPQRSTUVWX  9JZD-=u@0Gz@qh|:SMDL-00000485 -Bioorg. Med. Chem. Lett. 12(2)-2002 243-248 2d'CN(C)CCCCC1CC2N(O1)c3ccccc3Cc4ccccc24 {y TPeTARAcŊ02d)BE@^a.ʣң2\ %OWU:`;ei%(KOvKJV0'b4&>ޤ&$!ߊ-X8oG}&Ò ߊ,$&'()-+*,??abs570IC50 <6.0000@ receptorH1humancloned CHO cell antagonistP35367humanGPCRhistaminergic receptor[3H]pyrilamineY[\]^_`abcdefgh  dmsv@I+wy tx{IC50 <6.0000 receptor5-HT2Ahumancloned L929 cell antagonistP28223humanGPCRserotonergic receptor[125I]R-91150C} IC50 <6.0000 receptor5-HT2Chumancloned CHO cell antagonistP28335humanGPCRserotonergic receptor[3H]mesulergine0 e ~D38V-2x@uGz@5^I B SMDL-00000486@-Bioorg. Med. Chem. Lett. 12(2)-2002 243-2482i4O=C1N(CC2CC3N(O2)c4ccccc4Cc5ccccc35)C(=O)c6ccccc16捁 TPM ERBDK%S rA )CNhamdHe4Yxqx p@bȪcS#[``Fڲv#ږ#ΤZO3GT zhze_m03!>d&$!=<G&ѽ٢E 0,iklmnrpoq??abs8z|IC50 <6.00001 receptorH1human@cloned CHO cell antagonistP35367humanGPCRhistaminergic receptor[3H]pyrilamine y??3 antagonist67vp | p f \ V J > 6 0 h | t j ` R F < 2 (     @ R 8 0 &   H d  *   V  xnh\PHBzzpfZNF@~vndZL>4* 8*2<"L$"|pf\RF:2,rj dm   +  IC50 <6.0000 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150  !"#$  IC50 <6.0000 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine %'()*+,-./01234  &6D'(lw"Fs@ RQ @X9vSMDL-00000487 -Bioorg. Med. Chem. Lett. 12(2)-2002 243-248 2o(CN(C)C(=O)C1CC2N(O1)c3ccccc3Cc4ccccc24uuu`TPD"ua*F!R+Q T ><`!~5Xt.vus w5tvy5'6Fa,/,׼h&9& !U /8G&٢Eϖ U , abs  IC50 <6.0000 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamine5789:;<=>?@ABCD  dmOR + SU PTWIC50 <6.0000 receptor5-HT2Ahuman.cloned L929 cell4 antagonistP28223human3GPCRserotonergic receptor[125I]R-91150TY\]^_`abcdefghi IC50 <6.0000 receptor5-HT2Chumancloned CHO cell antagonistP28335humanGPCRserotonergic receptor[3H]mesulergine@jlmnopqrstuvwxy  Zk{D+?t@Q\(\ @%C[SMDL-00000488-Bioorg. Med. Chem. Lett. 12(2)-2002 243-2482p)C(C1CC2N(O1)c3ccccc3Cc4ccccc24)N5CCNCC5{ TPF"X Z*X:dJE:@1 t.vX Ҡ4y&ְ.RaXWV7,/,(9hq%%@!s,x9G}& e4n,EGHIJNLKM??cabsoVXuleIC50 <6.0000 receptorH1humancloned CHO cell antagonistP35367humanGPCRhistaminergic receptor[3H]pyrilaminez|}~ dm+ IC50 <6.0000 receptor5-HT2Ahumancloned L929 cellP28223 D7]hӸy@Gz@$SMDL-00000489-Bioorg. Med. Chem. Lett. 12(2)-2002 243-2482r3C(C1CC2N(O1)c3ccccc3Cc4ccccc24)N5CCN(CC5)c6ccccc6TPB95PTGHL1EPA )!DRQF^ԑqVa B 0ܩih j 1Q+-6ƭ6F+Jm^Ut2_A0!m15umeToU2)d#&3GGw z!(s,x8G&ؠD \(,??abs  ~ ~ F B| @  Jx ~ t j d X L D > v zpf\PD<6tldZPB4*  |.& . 8  D   |v(~tj`TH@:x^fp&,b(\,0 human GPCRserotonergic receptor [125I]R-91150 IC50 <6.0000 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine        IC50 <6.0000 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamine !"#$%  dm03 + 46 158IC50 <6.0000 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150 :=>?@ABCDEFGHIJ  IC50 <6.0000 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine KMNOPQRSTUVWXYZ  ;L\D7Y/{@2p= ף@Cl{ <SMDL-00000490 -Bioorg. Med. Chem. Lett. 12(2)-2002 243-248 2s5Clc1cccc(c1)N2CCN(CC3CC4N(O3)c5ccccc5Cc6ccccc46)CC2TPBE5PhDRO,xTS5ՔCTTB -F^QGQKR؇ޅSۄP0P y5yHolLۊhnKo8zQF؊zWL:]WFl]z[L.G%LdYLl[)Q;6; T!>K s,x8G'ؠD >Ka,&()*+/-,.??rabs79115IC50 <6.0000 receptorH1humancloned CHO cell antagonistP35367humanGPCRhistaminergic receptor[3H]pyrilamine[]^_`abcdefghij dmux+y{ vz}IC50 <6.0000 receptor5-HT2Ahumancloned L929 cell antagonistP28223humanGPCRserotonergic receptor[125I]R-91150 IC50 <6.0000 receptor5-HT2Chumancloned CHO cell antagonistP28335humanGPCRserotonergic receptor[3H]mesulergine @ D3Ġq8w@w@}?5^ISMDL-00000491-Bioorg. Med. Chem. Lett. 12(2)-2002 243-2482t.C(C1CC2N(O1)c3ccccc3Cc4ccccc24)N5Cc6ccccc6C5ƅTPP5PTQE5PB9$a]daQJRNF@ B&nj6DKfaoց]RokaA^y}]:s^yx]"0Nܟ'~ў &vj!s,x8G}&ؠD ,kmnoptrqs??abs|~?IC50 <6.0000 receptorH1humancloned CHO cell antagonistP35367humanGPCR 1 x r ~ | r f Z R L z p f X J @ 6 ,   D Z b l .  ^ ( & T .xl`XRvl^PF<2& Jt|48l.@n"4xndXLD>|, histaminergic receptor[3H]pyrilamine+   abs  IC50 <6.0000 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150  !"#$%&'  IC50 <6.0000 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine (*+,-./01234567  )9D' [ffr@333333@rh|SMDL-00000492 -Bioorg. Med. Chem. Lett. 12(2)-2002 243-248 2u$CN(C)CC1CC2N(O1)c3ccccc3Cc4ccccc24qes$TPF"X %BĂÆ&S }XEaSEݩ]xGלOwaxwԟS{.w;! !-x8G}&D˖  ,    ?? asu  IC50 <6.0000 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamine8:;<=>?@ABCDEFG  dmRU + VX SWZIC507.64007.64007.6400 receptor5-HT2Ahuman0cloned L929 cellC antagonistP28223human@GPCRserotonergic receptorX[125I]R-91150\_`abcdefghijklmn  IC507.91007.91007.9100 receptor5-HT2Chumancloned CHO cell antagonistP28335human@GPCRserotonergic receptor[3H]mesulergine@oqrstuvwxyz{|}~ @ ]pD' [ffr@T333333@rh|^SMDL-00000493C-Bioorg. Med. Chem. Lett. 12(2)-2002 249-253@2C$CN(C)CC1CC2N(O1)c3ccccc3Cc4ccccc24oes TPF"X !JĂÆ(S UuH`PџWIkZ#TIO=,Y=$Td$TٌzH_KzLz1]cdD`_!-x8G}&D˖ ,HJKLMQONP??absY[IC508.17008.17008.1700 receptorH1humancloned CHO cell antagonistP35367humanGPCRhistaminergic receptor[3H]pyrilamine dmoni+tept IC507.32007.32007.3200 receptor   D)ĠiQFs@ffffff@S㥛SMDL-00000494-Bioorg. Med. Chem. Lett. 12(2)-2002 249-2533a'CN(C)CC1CC2N(O1)c3ccccc3Cc4cccc(C)c24suu TP E0U, J$i-Z2Rg6<!?>7״WzH(v&zHȈGt%Xt%cĈX!)-x8G&D˖ ),??abs 0 &    < nv n 2 h 8 & :h ~ x , zt.rh^TH>4*"l` h r h $ b 2 , Z 2DB(  VvnhBJT,Z2<N*ZHV 5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150 IC507.52007.52007.5200 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine     IC507.93007.93007.9300 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamine !"#$%&'()*+,-./  dm:= + >@ ;?BIC507.98007.98007.9800 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150 DGHIJKLMNOPQRSTUV  IC508.20008.20008.2000 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine WYZ[\]^_`abcdefgh  EXjD)ĠiQFs@<ffffff@S㥛FSMDL-00000495-Bioorg. Med. Chem. Lett. 12(2)-2002 249-2533b'CN(C)CC1CC2N(O1)c3ccccc3Cc4cc(C)ccc24@suu T(QU0!C'Z,|T( 0"Z2Rh-<!BGBw̗+Ʊv}x˸׺we8Ghh$w=2!-x8G}&D˖ co,023459768??absACIC507.80007.80007.8000 receptorH1humancloned CHO cell antagonistP35367humanGPCRhistaminergic receptor[3H]pyrilamineiklmnopqrstuvwxyz dm+ IC508.16008.16008.1600 receptor5-HT2Ahumancloned L929 cell antagonistP28223humanGPCRserotonergic receptor[125I]R-91150 IC508.33008.33008.3300 receptor5-HT2Chumancloned CHO cell antagonistP28335humanGPCRserotonergic receptor@[3H]mesulergine @ D'E )?s@@V-SMDL-00000496-Bioorg. Med. Chem. Lett. 12(2)-2002 249-2533c'CN(C)CC1CC2N(O1)c3ccc(F)cc3Cc4ccccc24uuu TPEeԠB' XP/$Z2J<!  ݶ ]m>{^wa>_^"6BfVc,cv!R %ncUǢS`#!-x8G}'D˖ &,{}~??absIC50       nb H @ 6 ,    v | r j d   @ F P * V 0 : v R z h " ~ z`XND6* " rXPF<."zt$.PV`:f@J`x2ph^TF:0&  2(<pVND:, v8.89008.89008.8900 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilaminedm +  !IC508.46008.46008.4600 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150 #&'()*+,-./012345  IC508.98008.98008.9800 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine 689:;<=>?@ABCDEFG  $7ID't3t@@x&%SMDL-00000497 -Bioorg. Med. Chem. Lett. 12(2)-2002 249-253 3d(CN(C)CC1CC2N(O1)c3cc(Cl)ccc3Cc4ccccc24uuu TPU C'pP/$Z2J<! @\k.zN2vអNꡞ"#AZ^Uҕ Bf*"mZŎC# !s -x8G}'D˖ .s ,?? abs  " IC508.63008.63008.6300 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamineHJKLMNOPQRSTUVWXY  dmdg +hj eilIC508.51008.51008.5100 receptor5-HT2Ahumancloned L929 cell antagonistP28223humanGPCRserotonergic receptore[125I]R-91150(nqrstuvwxyz{|}~ IC508.52008.52008.5200 receptor5-HT2Chumancloned CHO cell antagonistP28335human GPCRserotonergic receptor[3H]mesulergine@  oD)ĠiQFs@fffffff@S㥛pSMDL-00000498e-Bioorg. Med. Chem. Lett. 12(2)-2002 249-253l3e'CN(C)CC1CC2N(O1)c3cc(C)ccc3Cc4ccccc24esuu TPU C'Z,|T( /"Z2F<!0?>'˷F̗zا(ֱzxwاt5؊cdtU}7!-x8G}&D˖ ,Z\]^_ca`b??abskmIC508.23008.23008.2300 receptorH1humancloned CHO cell antagonistP35367humanGPCRhistaminergic receptor[3H]pyrilamine dm.+u0  D't3t@@x&SMDL-00000499-Bioorg. Med. Chem. Lett. 12(2)-2002 249-2533g(CN(C)CC1CC2N(O1)c3c(Cl)cccc3Cc4ccccc24uuu TPEeԠ,V2h- Z2*B<!n.|Nxa2NZ!"CZҕf9X#Z^c-"#BҕȎC`#!/$-x8G'L˖ ./,??abs Zbl X  R "  &T ~ t n b X N D < 6 vlbVLB80*z z`XND6(  " & 0  H   ~rh^TLFzpdZPF>8nf\RD6," 0.6@,V&(zrh^PD:0* rIC507.49007.49007.4900 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150      IC507.99007.99007.9900 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine  !"#$  &IC507.81007.81007.8100 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamine%'()*+,-./0123456  dmAD + EG BFIIC507.17007.17007.1700 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150 KNOPQRSTUVWXYZ[\]  IC508.12008.12008.1200 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine^`abcdefghijklmno  L_qD)R8_v@C ףp= @(\MSMDL-00000500-Bioorg. Med. Chem. Lett. 12(2)-2002 249-2533i.CN(C)CC1CC2N(O1)c3ccccc3Cc4cccc(c24)C(F)(F)F{ P(B DJU)J(BC&ňA1JLь5!cxџ#WZI#sKY=_KTI+O=,79:;<@>=???absHJIC507.32007.32007.3200 receptorH1humancloned CHO cell antagonistP35367humanGPCRhistaminergic receptor[3H]pyrilamineprstuvwxyz{|}~ dm+}8 IC506.52006.52006.5200 receptor5-HT2Ahumancloned L929 cell antagonistP28223humanGPCRserotonergic receptor[125I]R-91150 IC507.71007.71007.7100 receptor5-HT2Chumancloned CHO cell antagonistP28335human      D)Ġ(_FFt@Q@p= ףSMDL-00000501-Bioorg. Med. Chem. Lett. 12(2)-2002 249-2533j&COc1ccc2Cc3ccccc3N4OC(CN(C)C)CC4c2c1yw PU0 C'Z,|TE".dDdNR[x @C#2Ͻq-%ɬN*ŧJ*2n=N*]lF-2q0z%=6/]vj" /!g -x8G}&D˖ g,??abs   $ t j ` V N H  bjt$ * 4  :   ^ & X (  .\^ D < 2 (    p  @& TzndZPHB$.4hDXFpX>6,"j|rh^VP |rdVLB8," zGPCRserotonergic receptor [3H]mesulergine IC507.84007.84007.8400 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamine              dm #  + $ &  ! % ( IC507.27007.27007.2700 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150 * - . / 0 1 2 3 4 5 6 7 8 9 : ; <   IC507.97007.97007.9700 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine = ? @ A B C D E F G H I J K L M N   + > P D'E )?s@" @V-, SMDL-00000502 -Bioorg. Med. Chem. Lett. 12(2)-2002 249-253 3k'CN(C)CC1CC2N(O1)c3ccccc3Cc4ccc(F)cc24 uuu PU0 C'pP/$Z2R)i-<! ܹ\2~NZp.aNz!"#[cU!C`fT#LoEZYUʎ%B /" !k-x8G}'D˖ &k ,         ?? abs ' )  IC508.42008.42008.4200 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamineO Q R S T U V W X Y Z [ \ ] ^ _ `   dmk n +.o q 0 l p s IC507.50007.50007.5000 receptor5-HT2Ahumancloned L929 cell antagonistP28223humanGPCRserotonergic receptor[125I]R-91150u x y z { | } ~   0IC507.93007.93007.9300 receptor5-HT2ChumanHcloned CHO cell antagonistP28335humantGPCRserotonergic receptori[3H]mesulergine   v D'E )?s@m @V-w SMDL-00000503.-Bioorg. Med. Chem. Lett. 12(2)-2002 249-2533l'CN(C)CC1CC2N(O1)c3ccccc3Cc4c(F)cccc24@uuu T(QCePT!,V2衤- Z: )hQ*<!""|rZV_nRF#ƘxrZ#Ȋ&~C~X#k`+Ȳ#j`-"#!-x8G'D˖ &),a c d e f j h g i ??0absr t ed.IC508.64008.64008.6400 receptorH1humanFcloned CHO cell antagonistP35367humangGPCRhistaminergic receptor[3H]pyrilamine  .D)R8_v@" ףp= @(\"SMDL-00000504-Bioorg. Med. Chem. Lett. 12(2)-2002 249-2533n!0/}8g&D˖ , "" "??histaminergic receptorclonedGPCRvlR l L x l b X R F < 2 (  d | n b X N D 8 . $   \ \B:0& d n   z * r zpf`TJ@6.(r|pf\RF<2( jjPH>4&r|"8 ~tnbXND<6" ~dm"" + " " " " "IC506.00006.00006.0000 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150 """""""""""""""" "  IC506.36006.36006.3600 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine !"#"$"%"&"'"(")"*"+","-"."/"0"1"2"  """4".CN(C)CC1CC2N(O1)c3ccccc3Cc4c(cccc24)C(F)(F)F{ AQPAQ*L0тC$ƈA1SZDь!cPѨW+YFlZQ\K݃$Tm$TOFQ#’4\6ٕ_ԫi|HKc:bDh >0 abs  " " IC507.43007.43007.4300 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamine3"5"6"7"8"9":";"<"=">"?"@"A"B"C"D"  dmO"R" + S"U" P"T"W"IC507.62007.62007.6200 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150 Y"\"]"^"_"`"a"b"c"d"e"f"g"h"i"j"k" *IC508.30008.30008.3000 receptor5-HT2Chumancloned CHO cell antagonistP28335human@GPCRserotonergic receptor[3H]mesulerginel"n"o"p"q"r"s"t"u"v"w"x"y"z"{"|"}"  Z"m""D'E )?s@Q"@V-["SMDL-00000505-Bioorg. Med. Chem. Lett. 12(2)-2002 249-253@3q'CN(C)CC1CC2N(O1)c3cccc(F)c3Cc4ccccc24uuu TD*eP!,V 2衤- Z: *%B<!"nRx|rZVF#XrX#ȊbC~~^##j`-"Ȳk`+#!-x8G'D˖ &0,E"G"H"I"J"N"L"K"M"??absnV"X"llIC508.76008.76008.7600 receptorH1human@cloned CHO cell antagonistP35367human"GPCRhistaminergic receptor[3H]pyrilamine~""""""""""""""""" dm""|+#""k` """IC507.04007.04007.0400 receptor5-HT2Ahuman0cloned L929 cell antagonistP28223human@GPCRserotonergic receptor[125I]R-911502""""""""""""""""" ] @ "$$D)ĠiQFs@"ffffff@S㥛"SMDL-00000506@-Bioorg. Med. Chem. Lett. 12(2)-2002 249-2533r'CN(C)CC1CC2N(O1)c3cccc(C)c3Cc4ccccc24suu TPE"ePT!,J0Ҋ-Z: *><!GG7&شGH1VxH|% ȈXȈ|%lX!-x8G&D˖ 0,"""""""""??abs0"""??human@""f` x n d Z R L  HPZ( . 8  >  " H r B  Bb H @ 6 ,    t X>6,"l|rh`Z  6<F L&0l H p^t pVND:,  8 L|rf\RH@:&,( pIC508.41008.41008.4100 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine "$$$$$$$ $ $ $ $ $$$$$IC508.22008.22008.2200 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamine$$$$$$$$$$$$$ $!$"$#$  dm.$1$ + 2$4$ /$3$6$IC508.94008.94008.9400 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150 8$;$<$=$>$?$@$A$B$C$D$E$F$G$H$I$J$  IC508.94008.94008.9400 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine K$M$N$O$P$Q$R$S$T$U$V$W$X$Y$Z$[$\$  9$L$^$D'E )?s@0$@V-:$SMDL-00000507 -Bioorg. Med. Chem. Lett. 12(2)-2002 249-253 3s'CN(C)CC1CC2N(O1)c3cc(F)ccc3Cc4ccccc24 uuu TPU C'pP/$Z2J<! l.zN2_vaNZ"AZUc BfT+bmZ^֣ҕƎC #!s-x8G}'D˖ &s ,$$&$'$($)$-$+$*$,$??tabs-5$7$ IC508.59008.59008.5900 receptorH1humanocloned CHO cell antagonistP35367humanGPCRhistaminergic receptor[3H]pyrilamine]$_$`$a$b$c$d$e$f$g$h$i$j$k$l$m$n$ dmy$|$]me+}$$$ z$~$$IC507.97007.97007.9700 receptor5-HT2Ahumancloned L929 cell antagonistP28223humanGPCRserotonergic receptor [125I]R-91150e$$$$$$$$$$$$$$$$$ IC508.21008.21008.2100 receptor5-HT2Chumancloned CHO cell antagonistP28335humanGPCRserotonergic receptorC[3H]mesulergine7$$$$$$$$$$$$$$$$$  $$$D'@j+t@{$@ r$SMDL-00000508-Bioorg. Med. Chem. Lett. 12(2)-2002 249-2533t*CN(C)CC1CC2N(O1)c3cc(F)ccc3Cc4ccc(F)cc24{w T(Q,% BXH0bȐqP%SLlx @D$A?>״7&zXzH(vFHtň(UX}ۗ'ct!-x8G}'D˖ ,o$q$r$s$t$x$v$u$w$??abs$$$IC507.77007.77007.7700 receptorH1humancloned CHO cell antagonistP35367humanGPCR[3H]pyrilamine$$$$$$$$$$$$$$$ $  z t h ^ T J B < l | r h ^ R H > 4 , & v v \ T J @ 2 $    ~  $ , 6  F   zndZPHBvl`VLB:4jbXN@2(,*2<(R"$|rh^VPzpbVLB8," tdm & & + && &&&IC507.65007.65007.6500 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150 &&&&&&&&&& &!&"&#&$&%&&&  IC507.95007.95007.9500 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine '&)&*&+&,&-&.&/&0&1&2&3&4&5&6&7&8&  &(&:&D3Ԡc@'w@ &= ףp=@Zd&SMDL-00000509 -Bioorg. Med. Chem. Lett. 12(2)-2002 249-253 3u.CN(C)CC1CC2N(O1)c3cc(ccc3Cc4ccccc24)c5ccccc5ƁTPB 8QBhԁ1PЃEUHFRJRL!h._vNZ2r=ZؿN"BQ&mҕfZ^֣穜YҕŽC`` !-x8G&D  ,"&&&& &&&&abs && IC508.10008.10008.1000 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamine9&;&<&=&>&?&@&A&B&C&D&E&F&G&H&I&J&  dmU&X& + Y&[& V&Z&]&IC50 <6.0000L receptor5-HT2Ahuman.cloned L929 cell5 antagonistP28223humancGPCRserotonergic receptorT[125I]R-91150_&b&c&d&e&f&g&h&i&j&k&l&m&n&o& IC50 <6.0000 receptor5-HT2Chuman&cloned CHO cell antagonistP28335humanGPCRserotonergic receptor[3H]mesulerginep&r&s&t&u&v&w&x&y&z&{&|&}&~&&  `&q&&D'E )?s@W&@V-a&SMDL-00000510-Bioorg. Med. Chem. Lett. 12(2)-2002 249-2533h'CN(C)CC1CC2N(O1)c3ccccc3Cc4cccc(F)c24@uuu PU0ՠ,V*h- Z2R)h1:<!^9 /gZ,ަ#$d.'Vn_P%`e{$U.S$e!/-x8G'D˖ &/&,K&M&N&O&P&T&R&Q&S&??abs\&^&}&IC50 <6.0000 receptorH1humancloned CHO cell antagonistP35367humanGPCRhistaminergic receptor[3H]pyrilamine&&&&&&&&&&&&&&& @dm&&+&&& &&&IC50 <6.0000 receptor5-HT2A&&&&&&" (((((((  (D)R8_v@& ףp= @(\&SMDL-00000511-Bioorg. Med. Chem. Lett. 12(2)-2002 249-2533m.CN(C)CC1CC2N(O1)c3ccccc3Cc4ccc(cc24)C(F)(F)F{ PT D )Ja„ ѠQ1RLՌ!d^Cd׳܁v%lutL+q@ [tlᜌjtj l{YSĺDXTfj2Q@R!8/}8g&D˖ >8,&&&&&&&&&??abs&&&(     2 z d > ^ .  Ft * 4vl`TLFp x "(2 8n 4  h 8 & < j \B:0& n8 L|rf\RH@:&,lHP>t  L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150 IC50 <6.0000 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine ( ( ( ((((((((((((  & ((IC50 <6.0000 receptorH1human cloned CHO cell antagonistP35367human GPCRhistaminergic receptor[3H]pyrilamine(((((( (!("(#($(%(&('(((  dm3(6( + 7(9( 4(8(;(IC50 <6.0000 receptor5-HT2Ahuman cloned L929 cell antagonistP28223human GPCRserotonergic receptor [125I]R-91150 =(@(A(B(C(D(E(F(G(H(I(J(K(L(M(  IC50 <6.0000 receptor5-HT2Chuman cloned CHO cell antagonistP28335human GPCRserotonergic receptor [3H]mesulergine N(P(Q(R(S(T(U(V(W(X(Y(Z([(\(](  >(O(_(D't3t@5(@x&?(SMDL-00000512 -Bioorg. Med. Chem. Lett. 12(2)-2002 249-253 3p(CN(C)CC1CC2N(O1)c3ccccc3Cc4c(Cl)cccc24uuu T(QCePT!,V2衤- Z: )hQ*<!2\9/! c,3P.KF{(dC :`%'b{U.w&$ ! -x8G'D˖ r.T,)(+(,(-(.(2(0(/(1(??abs3:(<(@GPIC50 <6.0000o receptorH1humancloned CHO cell antagonistP35367humanGPCRhistaminergic receptor[3H]pyrilamine^(`(a(b(c(d(e(f(g(h(i(j(k(l(m( y(Ki8.69908.69908.6990 receptorsigma2rat membranebrain antagonist[3H]-1,3-di-o-tolylguanidine(+)-pentazocine@|((((((((((((((GKi8.39798.39798.3979 receptor5-HT1Arat membranecortex; brain antagonistGPCRserotonergic receptor[3H]prazosin(((((((((((((((G Ki7.00007.00007.0000 receptor5-HT2Arat@ membranehippocampus; brain antagonistP14842rat@GPCRserotonergic receptor[3H]-8-OH-DPAT((((((((((((((((( 2 r }(((**#*5*G*Drrd+ĠS" v@z(@~(SMDL-00002162p/Bioorg. Med. Chem. Lett. 12(8)-2002 1149-11526L*Cn1c(=O)sc2cc(CCN3CCC(CC3)c4ccccc4)ccc12}y TQ` Bh+W*L YtiV@B8 tk}HznL9itL,[̐͐+[,z#+zIzn`/.ΐ/!Ҹ=,1.߳T Ҹ0,n(p(q(r(s(w(u(t(v(??ncx({((7.52297.5229~t | r f \ R H B < t l ^ L @ 8 . "    4 F &     Z ^dnR "~ L   *Xzt ~x vlbXL@82p\dn$Z T$(VH.&Z~rjd R80& Ki4.69904.69904.6990 receptor5-HT3 rat membranecortex; brain antagonistP35563rat ligand-gated ion channelserotonergic receptor [3H]ketanserin(******* * * * * *****Ki6.00006.00006.0000 receptorD2rat membranestriatum; brain antagonistGPCRdopaminergic receptor [3H]raclopride************* *!*G  Ki7.69907.69907.6990 receptorH1rat membranebrain antagonistP31390rat GPCRhistaminergic receptor[3H]pyrilamine"*$*%*&*'*(*)***+*,*-*.*/*0*1*2*3*  Ki6.00006.00006.0000 receptorm1rat membranebrain antagonistP08482rat GPCR; ion channel #muscarinic acetylcholine receptor [3H]telenzepine 4*6*7*8*9*:*;*<*=*>*?*@*A*B*C*D*E*  Ki7.69907.69907.6990 receptorsigma1rat membranebrain antagonistQ9R0C9rat [3H]-(+)-pentazocineG-protein sensibleF*H*I*J*K*L*M*N*O*P*Q*R*S*T*U*V* b*Ki8.52298.52298.5229 receptorsigma2ratr membranebrainz antagonist[3H]-1,3-di-o-tolylguanidine(+)-pentazocinee*h*i*j*k*l*m*n*o*p*q*r*s*t*GKi8.00008.00008.0000 receptor5-HT1Arat( membranecortex; braine antagonistGPCRserotonergic receptor*[3H]prazosinu*w*x*y*z*{*|*}*~*******G Ki6.39796.39796.3979 receptor5-HT2Arat membranehippocampus; brain antagonistP14842ratGPCRserotonergic receptor[3H]-8-OH-DPAT***************** Ki5.00005.00005.0000 receptor5-HT3rat membranecortex; brain antagonistP35563ratligand-gated ion channelserotonergic receptor[3H]ketanserin***************** nKi7.5229****((,,,,,,,, ,G f*v**** ,Dssd/,w@c*@#~jg*SMDL-00002163/Bioorg. Med. Chem. Lett. 12(8)-2002 1149-11527,Cn1c(=O)sc2cc(CCCCN3CCC(CC3)c4ccccc4)ccc12} TQf Bh+W*Lq0ፆdAA0BZ D4@=J' }~E4iJ'"Ѧv IO>5&z]p{Rd{*$ !=,1.߳T ,W*Y*Z*[*\*`*^*]*_*??nca*d**  F ,   X v n d X N D : 4 . f^P>2*  & 8  LrxT 6 N  >l|rhb\nf\ND80* TD*"Vzpjd ~tfTH@6*    receptorD2rat membranestriatum; brain antagonistGPCRdopaminergic receptor [3H]racloprideKi5.22185.22185.2218 receptorH1rat membranebrain antagonistP31390rat GPCRhistaminergic receptor[3H]pyrilamine , , ,,,,,,,,,,,,,,,  ',Ki8.30108.30108.3010 receptorsigma2rat membranebrain antagonist[3H]-1,3-di-o-tolylguanidine(+)-pentazocine *,-,.,/,0,1,2,3,4,5,6,7,8,9,G Ki8.39798.39798.3979 receptor5-HT1Arat membranecortex; brain antagonistGPCRserotonergic receptor [3H]prazosin:,<,=,>,?,@,A,B,C,D,E,F,G,H,I,G  Ki6.39796.39796.3979 receptor5-HT2Arat membranehippocampus; brain antagonistP14842rat GPCRserotonergic receptor [3H]-8-OH-DPATJ,L,M,N,O,P,Q,R,S,T,U,V,W,X,Y,Z,[,  Ki5.69905.69905.6990 receptor5-HT3 rat membranecortex; brain antagonistP35563ratligand-gated ion channelserotonergic receptor.[3H]ketanserin\,^,_,`,a,b,c,d,e,f,g,h,i,j,k,l,m, ,Ki <7.0000 receptorD2rat membranestriatum; brain antagonistGPCRdopaminergic receptor[3H]raclopriden,p,q,r,s,t,u,v,w,x,y,z,{,G eKi8.52298.52298.5229 receptorH1rat membranebrain antagonistP31390ratGPCRhistaminergic receptor[3H]pyrilamine|,~,,,,,,,,,,,,,,,, @+,;,K,],o,},,Dttd-Ԡ?xv@(,(\@S,,SMDL-00002164/Bioorg. Med. Chem. Lett. 12(8)-2002 1149-11528+Cn1c(=O)sc2cc(CCN3CCC(Cc4ccccc4)CC3)ccc12{ TQT B(FBSV&Nh X"pJ vrQܐVøSܪ/2k¸k۞!H=,1.߳T eH@,,,, ,!,%,#,",$,??nc&,),Ki7.00007.00007.0000 receptorm1rat membranebrain antagonistP08482ratoGPCR; ion channel1#muscarinic acetylcholine receptor)[3H]telenzepinec,,,,,,,,,,,,,,,,, Duud1uVx@.(\@m.SMDL-00002165/Bioorg. Med. Chem. Lett. 12(8)-2002 1149-11529-Cn1c(=O)sc2cc(CCCCN3CCC(Cc4ccccc4)CC3)ccc12}PBQQP e&TO,NDQU\hF CSBP@Bp4=>|AFơh1K"fyOPF@Yp){Tɟ Y" yh!! =,1.߳T  ,,,,,,,,,,??$,f T 0` .  \$ z t n 8 tj`VPJ xjVJB<0$BhN2* zzpf\VPr`TLB6," HZ:," nX ^ h D  r > $ R |*jPH:& .Ki8.30108.30108.3010 receptorsigma2rat membranebrain antagonist[3H]-1,3-di-o-tolylguanidine(+)-pentazocine ... . . . . .......G Ki7.52297.52297.5229 receptor5-HT1Arat membranecortex; brain antagonistGPCRserotonergic receptor [3H]prazosin........... .!.".#.G  Ki6.15496.15496.1549 receptor5-HT2Arat membranehippocampus; brain antagonistP14842rat GPCRserotonergic receptor [3H]-8-OH-DPAT$.&.'.(.).*.+.,.-.../.0.1.2.3.4.5.  Ki5.69905.69905.6990 receptor5-HT3 rat membranecortex; brain antagonistP35563rat ligand-gated ion channelserotonergic receptor [3H]ketanserin6.8.9.:.;.<.=.>.?.@.A.B.C.D.E.F.G.  Ki7.00007.00007.0000 receptorD2rat membranestriatum; brain antagonistGPCRdopaminergic receptor [3H]racloprideH.J.K.L.M.N.O.P.Q.R.S.T.U.V.W.G  Ki8.04588.04588.0458 receptorH1rat membranebrain antagonistP31390ratGPCRhistaminergic receptor[3H]pyrilamineX.Z.[.\.].^._.`.a.b.c.d.e.f.g.h.i. ..%.7.I.Y.k.nc.Ki6.69906.69906.6990 receptorm1rat membranebrain antagonistP08482ratGPCR; ion channel#muscarinic acetylcholine receptor[3H]telenzepinej.l.m.n.o.p.q.r.s.t.u.v.w.x.y.z.{. .Ki8.52298.52298.5229 receptorsigma2rat membranebrain@ antagonist[3H]-1,3-di-o-tolylguanidine(+)-pentazocine..............GKi7.52297.52297.5229 receptor5-HT1Arat membranecortex; brain antagonistGPCRserotonergic receptor@[3H]prazosin...............G @Ki5.52295.5229.....00000000 0 0 0 0 !0Dvvd+48Ev@.Q @ +.SMDL-00002166/Bioorg. Med. Chem. Lett. 12(8)-2002 1149-115210+Cn1c(=O)sc2cc(CCN3CCN(Cc4ccccc4)CC3)ccc12{ TQ\( `:+*Vh #R@k#h#A-Ne,N)_-u%+u-1e,81_-08^,e,) &00^-!=,1.߳T D@,|.~........??nc..?13@nc|   P 6 .   `  |  fv lvR * L   2`vh^RJD8.$n 0Bzpf\VPjbXJ8,$H4 FzndZPJDrdZNF<0& < 5.5229 receptor5-HT2Arat membranehippocampus; brain antagonistP14842rat GPCRserotonergic receptor [3H]-8-OH-DPATKi4.69904.69904.6990 receptor5-HT3 rat membranecortex; brain antagonistP35563rat ligand-gated ion channelserotonergic receptor [3H]ketanserin 00000000000000000  Ki <5.0000 receptorD2rat membranestriatum; brain antagonistGPCRdopaminergic receptor [3H]raclopride0"0#0$0%0&0'0(0)0*0+0,0-0G  Ki8.15498.15498.1549 receptorH1rat membranebrain antagonistP31390rat GPCRhistaminergic receptor[3H]pyrilamine.000102030405060708090:0;0<0=0>0?0  ...0 0/0A0Ki6.30106.30106.3010 receptorm1rat membranebrain antagonistP08482rat GPCR; ion channel #muscarinic acetylcholine receptor [3H]telenzepine @0B0C0D0E0F0G0H0I0J0K0L0M0N0O0P0Q0  ]0Ki8.69908.69908.6990 receptorsigma2rat membranebrain antagonist[3H]-1,3-di-o-tolylguanidine(+)-pentazocine`0c0d0e0f0g0h0i0j0k0l0m0n0o0GKi7.39797.39797.3979 receptor5-HT1Arat membranecortex; brain0 antagonistGPCRserotonergic receptor[3H]prazosinp0r0s0t0u0v0w0x0y0z0{0|0}0~00G Ki6.04586.04586.0458 receptor5-HT2Arat@ membranehippocampus; brain antagonistP14842ratTGPCRserotonergic receptor [3H]-8-OH-DPAT00000000000000000 Ki5.09695.09695.0969 receptor5-HT38rat4 membranecortex; brain antagonistP35563ratligand-gated ion channelserotonergic receptor[3H]ketanserin00000000000000000 Ki5.00005.00005.0000 receptorD2rat membranestriatum; brain antagonistGPCRdopaminergic receptor000000000000002G  a0q000022%2Dwwd/f6$#x@^0@B`"[b0SMDL-00002167/Bioorg. Med. Chem. Lett. 12(8)-2002 1149-115211-Cn1c(=O)sc2cc(CCCCN3CCN(Cc4ccccc4)CC3)ccc12}PB5EEAdSOu*RL8QU\hFDKQCP h@=edy!rȡh1K$"'P?Bm"`P9y<{$v塅bZ!=,1.߳T T,R0T0U0V0W0[0Y0X0Z0??nc\0_00 ~ t j d ^ x p f X F : 2 (    V B (   T |rh^XRrh\TJ>4*  Jnt~B 2r < :h\6 pxrf\RHB<rj\H<4." 4Z@$lrjbXJ4(  [3H]racloprideKi >7.0000 receptorH1rat membranebrain antagonistP31390rat GPCRhistaminergic receptor[3H]pyrilamine222222 2 2 2 2 22222  Ki5.00005.00005.0000 receptorm1rat membranebrain antagonistP08482rat GPCR; ion channel #muscarinic acetylcholine receptor [3H]telenzepine 2222222222222 2!2"2#2  Ki7.42957.42957.4295 receptorsigma1rat membranebrain antagonistQ9R0C9rat [3H]-(+)-pentazocineG-protein sensible$2&2'2(2)2*2+2,2-2.2/20212223242 @2Ki8.09698.09698.0969 receptorsigma2rat membranebrain antagonist[3H]-1,3-di-o-tolylguanidine(+)-pentazocine C2F2G2H2I2J2K2L2M2N2O2P2Q2R2G Ki7.00007.00007.0000 receptor5-HT1Arat membranecortex; brain antagonistGPCRserotonergic receptor [3H]prazosinS2U2V2W2X2Y2Z2[2\2]2^2_2`2a2b2G  Ki6.00006.00006.0000 receptor5-HT2Arat membranehippocampus; brain antagonistP14842ratGPCRserotonergic receptor[3H]-8-OH-DPATc2e2f2g2h2i2j2k2l2m2n2o2p2q2r2s2t2 .Ki4.69904.69904.6990 receptor5-HT3rat membranecortex; brain antagonistP35563ratligand-gated ion channelserotonergic receptor[3H]ketanserinu2w2x2y2z2{2|2}2~222222222 oKi7.00007.00007.0000 receptorD2rat@ membranestriatum; brain@ antagonistGPCRdopaminergic receptor@[3H]raclopride222222222222222G D2T2d2v222Dxxd+ |,}F{@A2Q@tE2SMDL-00002168/Bioorg. Med. Chem. Lett. 12(8)-2002 1149-1152121Cn1c(=O)sc2cc(CCN3CCN(Cc4ccc(Cl)cc4Cl)CC3)ccc12@}PB11QdF\PUURI9B<EQʃC` 01ZRZUUj f j>avWfņ vbo^Ʀf6a YƆ٘v`o GV!5 ,1.T d5t,52728292:2>2<2;2=2??gnc?2B212(Ki8.00008.00008.0000 receptorH1ratC membranebrain antagonistP31390ratGPCRhistaminergic receptor[3H]pyrilamine22222222222222222 oDyyd/  .V`}@4(\@S㥛 4SMDL-00002169/Bioorg. Med. Chem. Lett. 12(8)-2002 1149-1152,2222.4444??mbrane" T ~ , x n d Z T N h`VH6*" F 2DxlbXNHB~pbXLD:.$  :h n x < , p  6  4 b J2* `vlbXRLzrhZPD<6*D 4Ki8.04588.04588.0458 receptorsigma2rat membranebrain antagonist[3H]-1,3-di-o-tolylguanidine(+)-pentazocine 4 4 444444444444G Ki6.69906.69906.6990 receptor5-HT1Arat membranecortex; brain antagonistGPCRserotonergic receptor [3H]prazosin444444 4!4"4#4$4%4&4'4(4G  Ki6.04586.04586.0458 receptor5-HT2Arat membranehippocampus; brain antagonistP14842rat GPCRserotonergic receptor [3H]-8-OH-DPAT)4+4,4-4.4/404142434445464748494:4  Ki5.69905.69905.6990 receptor5-HT3 rat membranecortex; brain antagonistP35563rat ligand-gated ion channelserotonergic receptor [3H]ketanserin;4=4>4?4@4A4B4C4D4E4F4G4H4I4J4K4L4  Ki7.00007.00007.0000 receptorD2rat membranestriatum; brain antagonistGPCRdopaminergic receptor [3H]racloprideM4O4P4Q4R4S4T4U4V4W4X4Y4Z4[4\4G  Ki >7.0000 receptorH1rat membranebrain antagonistP31390ratGPCRhistaminergic receptor[3H]pyrilamine]4_4`4a4b4c4d4e4f4g4h4i4j4k4l4  44*4<4N4^4n43Cn1c(=O)sc2cc(CCCCN3CCN(Cc4ccc(Cl)cc4Cl)CC3)ccc12PB1![dPFSQTRHB^p1xYd@5.0000 receptorm1rat membranebrain antagonistP08482ratGPCR; ion channel.#muscarinic acetylcholine receptor[3H]telenzepinebm4o4p4q4r4s4t4u4v4w4x4y4z4{4|4 4Ki8.30108.30108.3010 receptorsigma2rat membranebrain antagonist[3H]-1,3-di-o-tolylguanidine(+)-pentazocine44444444444444G@Ki7.52297.52297.5229 receptor5-HT1Arat membranecortex; brain antagonist444444444444 66G 6Dzzd+ |,}F{@4Q@t4SMDL-00002170/Bioorg. Med. Chem. Lett. 12(8)-2002 1149-1152143Cn1c(=O)sc2cc(CCN3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)ccc12}PBMEA BD>a\PUQG-B8ĄEQQȂCP$1ZRZUUf ?avWf vojj o ^Ʀf6a Yf٘v`bGV!* =,1.߷\ d* ,}444444444??nc44???  ~ t n h  |b N @ H   Hv t l b T J > 6 0 $   Z 0zpf\VPjbXJ8,$H4 FzndZPJDrdZNF<0& < " serotonergic receptor [3H]prazosinKi5.30105.30105.3010 receptor5-HT2Arat membranehippocampus; brain antagonistP14842rat GPCRserotonergic receptor [3H]-8-OH-DPAT66666 6 6 6 6 66666666  Ki5.52295.52295.5229 receptor5-HT3 rat membranecortex; brain antagonistP35563rat ligand-gated ion channelserotonergic receptor [3H]ketanserin666666666 6!6"6#6$6%6&6'6  Ki6.69906.69906.6990 receptorD2rat membranestriatum; brain antagonistGPCRdopaminergic receptor [3H]raclopride(6*6+6,6-6.6/60616263646566676G  Ki7.39797.39797.3979 receptorH1rat membranebrain antagonistP31390rat GPCRhistaminergic receptor[3H]pyrilamine86:6;6<6=6>6?6@6A6B6C6D6E6F6G6H6I6  4466)696K6Ki6.00006.00006.0000 receptorm1rat membranebrain antagonistP08482rat GPCR; ion channel #muscarinic acetylcholine receptor [3H]telenzepine J6L6M6N6O6P6Q6R6S6T6U6V6W6X6Y6Z6[6  f6Ki8.69908.69908.6990 receptorsigma2ratR membranebraine antagonist[3H]-1,3-di-o-tolylguanidine(+)-pentazocinei6l6m6n6o6p6q6r6s6t6u6v6w6x6GKi6.52296.52296.5229 receptor5-HT1Arat1 membranecortex; brain antagonistGPCRserotonergic receptorh[3H]prazosiny6{6|6}6~66666666666G Ki5.00005.00005.0000 receptor5-HT2Arat membranehippocampus; brain antagonistP14842ratGPCRserotonergic receptor[3H]-8-OH-DPAT66666666666666666 Ki4.52294.52294.5229 receptor5-HT3rat membranecortex; brain@ antagonistP35563ratligand-gated ion channelserotonergic receptor@[3H]ketanserin66666666666666666 dG c j6z66688#858D{{d/  .V`}@g6(\@S㥛k6SMDL-00002171/Bioorg. Med. Chem. Lett. 12(8)-2002 1149-1152155Cn1c(=O)sc2cc(CCCCN3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)ccc12PBIEA BD>aDSQuQI1^p1xYT@,x0A!PYsLAAgYh$n)h-!yyKŸ' )Jw&'b?mHnOYPfAYcT! =,1.߷\ 3t,4]6^6_6`6d6b6a6c6nce6h6GPCRhistaminergic receptor3ptjbX r j ` R @ 4 , "   P < "    N vlbXRL zlbVND8.$` DLR\ J V0jzrl`VLB<6zldVB6.(.B( T~rj`TJ@60*~ Ki7.00007.00007.0000 receptorD2rat membranestriatum; brain antagonistGPCRdopaminergic receptor [3H]raclopride68888888 8 8 8 8 888Ki8.04588.04588.0458 receptorH1rat membranebrain antagonistP31390rat GPCRhistaminergic receptor[3H]pyrilamine888888888888888 8!8  Ki6.30106.30106.3010 receptorm1rat membranebrain antagonistP08482rat GPCR; ion channel #muscarinic acetylcholine receptor [3H]telenzepine "8$8%8&8'8(8)8*8+8,8-8.8/808182838  Ki6.85706.85706.8570 receptorsigma1rat membranebrain antagonistQ9R0C9rat [3H]-(+)-pentazocineG-protein sensible4868788898:8;8<8=8>8?8@8A8B8C8D8 + O8R8 P8T8Ki5.69905.69905.6990 receptorsigma2rat membranebrain antagonist[3H]-1,3-di-o-tolylguanidine(+)-pentazocine V8Y8Z8[8\8]8^8_8`8a8b8c8d8e8G Ki <5.0000 receptor5-HT1Arate membranecortex; brain antagonistGPCRserotonergic receptor[3H]prazosinf8h8i8j8k8l8m8n8o8p8q8r8s8G Ki <5.0000 receptor5-HT2Arat membranehippocampus; brain antagonistP14842ratGPCRserotonergic receptor[3H]-8-OH-DPATt8v8w8x8y8z8{8|8}8~888888 Ki <5.0000 receptor5-HT3cratb membranecortex; brain antagonistP35563ratrligand-gated ion channelserotonergic receptor[3H]ketanserin888888888888888 Ki <5.0000 receptorD2rat membranestriatum; brain antagonistGPCRdopaminergic receptor[3H]raclopride8888888888888G Ki4.69904.69904.6990 receptorH1rat membranebrain antagonistP31390rat8888888888888866: W8g8u8888:D||d!]s@Q8GzG@EX8SMDL-00002172/Bioorg. Med. Chem. Lett. 12(8)-2002 1149-115216/C[C@H]1CN(CCc2ccc3n(C)c(=O)sc3c2)C[C@@H](C)N1qUo$TQ^*P+WLPP +I: k>\jEyE*PPkYy3]Yl›*wccAim+ !=,1.߳Կ $,E8G8H8I8J8N8L8K8M8??absS8U88   z t n  v h V J B 8 ,   f dJB:0" v ,zpf`Z lt~:P@Jf 0 ` .  8fnf\ND80&2>Rxrf\RHB<zrdPD<6*   [3H]pyrilamineKi <5.0000 receptorm1rat membranebrain antagonistP08482rat GPCR; ion channel #muscarinic acetylcholine receptor [3H]telenzepine :::::: : : : : :::::  + :: :!:Ki7.00007.00007.0000 receptorsigma2rat membranebrain antagonist[3H]-1,3-di-o-tolylguanidine(+)-pentazocine #:&:':(:):*:+:,:-:.:/:0:1:2:G Ki <4.0000 receptor5-HT1Arat membranecortex; brain antagonistGPCRserotonergic receptor [3H]prazosin3:5:6:7:8:9:::;:<:=:>:?:@:G  Ki <4.0000 receptor5-HT2Arat membranehippocampus; brain antagonistP14842rat GPCRserotonergic receptor [3H]-8-OH-DPATA:C:D:E:F:G:H:I:J:K:L:M:N:O:P:  Ki <4.0000 receptor5-HT3 rat membranecortex; brain antagonistP35563rat ligand-gated ion channelserotonergic receptor [3H]ketanserinQ:S:T:U:V:W:X:Y:Z:[:\:]:^:_:`:  Ki <4.0000 receptorD2rat membranestriatum; brain antagonistGPCRdopaminergic receptor[3H]raclopridea:c:d:e:f:g:h:i:j:k:l:m:n:G Ki <4.0000 receptorH1rat membranebrain antagonistP31390ratGPCRhistaminergic receptor[3H]pyrilamineo:q:r:s:t:u:v:w:x:y:z:{:|:}:~: $:4:B:R:b:p::D}}d%1_^t@:(\ @V- %:SMDL-00002173@/Bioorg. Med. Chem. Lett. 12(8)-2002 1149-1152171C[C@H]1CN(CCCCc2ccc3n(C)c(=O)sc3c2)C[C@@H](C)N1:yus$TQd*P+WL@ 1n#e`b @H(k Mr+yA2 AR#y+!RshhrwR㥠wݏڞ޶r!=,1.߳Կ 4,:::::::::??abs :":Ki <4.0000 receptorm1rat membranebrain antagonistP08482ratGPCR; ion channel@#muscarinic acetylcholine receptor[3H]telenzepine::::::::::::::: :Ki7.57007.5700:::::<<<<<<<< < < < < < #<D'(Hris@:> ףp= @I + :SMDL-000045030Bioorg. Med. Chem. Lett. 12(15)-2002 2031-20344"CCCCCC(=O)c1ccc(OCCCN2CCNCC2)cc1quq`ġXB)lQ3BrJ 6hx DD{1/D1ey eK /%H&JFDFdHX/XkkQfm!m D0@ 1 Sqm,:::::::::??nc:::<eP F @ : Z 4  J & V D R \ F > 4 &     , X>6.$ j 0xpfZNHBxph^P:.&:J0(Z ( h~nx f ~ l & zrhZPD<6*` 7.5700 receptorH3rat membranecortex; brain antagonistQ9QYN8rat GPCRhistaminergic receptor![3H]-(R)-Nalpha-methylhistamine thioperamideKi5.22005.22005.2200 receptorH1human membranecloned antagonistP35367human GPCRhistaminergic receptor![3H]-(R)-Nalpha-methylhistamine thioperamide<<<<<<<<<<<<<<<<< <  :<"<Ki4.84004.84004.8400 receptorH2human membranecloned antagonistP25021human GPCRhistaminergic receptor![3H]-(R)-Nalpha-methylhistamine thioperamide!<$<%<&<'<(<)<*<+<,<-<.</<0<1<2<3<4<  @<Ki8.52008.52008.5200 receptorH3rat membranecortex; brain antagonistQ9QYN8rat GPCRhistaminergic receptor![3H]-(R)-Nalpha-methylhistamine thioperamideC<F<G<H<I<J<K<L<M<N<O<P<Q<R<S<T<U<V<  Ki5.97005.97005.9700 receptorH1human membranecloned antagonistP35367human GPCRhistaminergic receptor![3H]-(R)-Nalpha-methylhistamine thioperamideW<Y<Z<[<\<]<^<_<`<a<b<c<d<e<f<g<h<i<  D<X<k<D+H:w@A<(\@nE<SMDL-000045040Bioorg. Med. Chem. Lett. 12(15)-2002 2031-20345+CCCCCC(=O)c1ccc(OCCCN2CCN(CC2)C(=O)OC)cc1@y  E$DTDxp $fG&(:@ dPKxʟPKkF㘤h) BjBFqiQ3=U1iUkyژa e!AL&󀴇Q 1 DSqmA@,5<7<8<9<:<><<<;<=<??nc?<B<Ki4.92004.92004.9200 receptorH2human membranecloned antagonistP25021humanGPCRhistaminergic receptor![3H]-(R)-Nalpha-methylhistaminethioperamidej<l<m<n<o<p<q<r<s<t<u<v<w<x<y<z<{<|< <Ki8.86008.86008.8600 receptorH3rat membranecortex; brain antagonistQ9QYN8ratGPCRhistaminergic receptor![3H]-(R)-Nalpha-methylhistaminethioperamide<<<<<<<<<<<<<<<<<< Ki6.56006.56006.5600 receptorH1human membranecloned antagonistP35367humanGPCRhistaminergic receptor![3H]-(R)-Nalpha-methylhistamine<<<<<<<<<<<<<<<<<>  <<>D-H\='ohx@<= ףp=@zG<SMDL-000045050Bioorg. Med. Chem. Lett. 12(15)-2002 2031-20346A-923,CCCCCC(=O)c1ccc(OCCCN2CCN(CC2)C(=O)OCC)cc1{  E$DTDxp $fǍLQt @ ?S58* |X>6," "jbZPB0$ thioperamideKi4.90004.90004.9000 receptorH2human membranecloned antagonistP25021human GPCRhistaminergic receptor![3H]-(R)-Nalpha-methylhistamine thioperamide>>>>>> > > > > >>>>>>>>   >Ki7.69007.69007.6900 receptorH3rat membranecortex; brain antagonistQ9QYN8rat GPCRhistaminergic receptor![3H]-(R)-Nalpha-methylhistamine thioperamide#>&>'>(>)>*>+>,>->.>/>0>1>2>3>4>5>6>  Ki6.24006.24006.2400 receptorH1human membranecloned antagonistP35367human GPCRhistaminergic receptor![3H]-(R)-Nalpha-methylhistamine thioperamide7>9>:>;><>=>>>?>@>A>B>C>D>E>F>G>H>I>  $>8>K>D14H>M)z@!>)\(@Zd;O %>SMDL-00004506 0Bioorg. Med. Chem. Lett. 12(15)-2002 2031-20347 .CCCCCC(=O)c1ccc(OCCCN2CCN(CC2)C(=O)OCCCC)cc1}T TPD!RG AC!DLDWpZlE(t Q >4<$R-ơ 4dH;>-ҌaH"R+# Ҍ0[Ӳe.Sy.S o+-CB!3!1ӽAt !IL&󀴇Q 1 DSq I ,>>>>>>>>>?? nc>"> Ki5.73005.73005.7300 receptorH2human membranecloned antagonistP25021human GPCRhistaminergic receptor![3H]-(R)-Nalpha-methylhistamine thioperamideJ>L>M>N>O>P>Q>R>S>T>U>V>W>X>Y>Z>[>\> h>Ki8.30008.30008.3000 receptorH3rat membranecortex; brain antagonistQ9QYN8ratGPCRhistaminergic receptor![3H]-(R)-Nalpha-methylhistaminethioperamidek>n>o>p>q>r>s>t>u>v>w>x>y>z>{>|>}>~> LKi6.51006.51006.5100 receptorH1humanu membranecloned antagonistP35367humanuGPCRhistaminergic receptor![3H]-(R)-Nalpha-methylhistaminemthioperamide>>>>>>>>>>>>>>>>>>  l>>>D/$H#Hy@i>Q@ʡEm>SMDL-00004507@0Bioorg. Med. Chem. Lett. 12(15)-2002 2031-20348@/CCCCCC(=O)c1ccc(OCCCN2CCN(CC2)C(=O)OC(C)C)cc1} DAN0%HPxp$L̰Q;D+@@Ijx(~'ZWħjAc.A$~ZvA%C.%ħAa渦e\\WZfUAeUECjhhc|!\\+&󀴗Q|1 Dsqe\.,]>_>`>a>b>f>d>c>e>??Cncg>j>)C)Ki4.75004.75004.7500 receptorH2human membranecloned antagonistP25021humanGPCRhistaminergic receptor![3H]-(R)-Nalpha-methylhistamine5thioperamide>>>>>>>>>>>>>>>>>> D14H>M)z@ @zG@ @SMDL-000045080,>>>@@@@@@??L membrane@~8 JxD  T v p d Z P F @ :  hNF>4&